578: Fetoscopic spina bifida repair leads to prenatal reversal of hindbrain herniation

Fetoscopic repair of spina bifida: safer and better?

†Fetal Therapy Program, Albert Einstein Hospital, São Paulo, Brazil; ‡Office of the Dean and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA; §Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; ¶Department of Obstetrics and Gynecology, University ...

Fetoscopic versus Open Repair for Spina Bifida Aperta: A Systematic Review of Outcomes.

OBJECTIVE To compare outcomes of fetoscopic spina bifida aperta repair (FSBAR) with the results of the open approach (OSBAR) as in the Management Of Myelomeningocele Study (MOMS). METHODS This was a systematic comparison of reports on FSBAR with data from the MOMS (n = 78). Inclusion criteria were studies of spina bifida aperta patients who underwent FSBAR and were followed for ≥12 months. Pr...

Spina Bifida (Myelomeningocele)

Orthopedic management of spina bifida.

The management of orthopedic problems in spina bifida has seen a dramatic change over the past 10 years. The negative effects of spasticity, poor balance, and the tethered cord syndrome on ambulatory function are better appreciated. There is less emphasis on the hip radiograph and more emphasis on the function of the knee and the prevention of knee pain. The importance of the hip abductor muscl...

Mosaic expression of Med12 in female mice leads to exencephaly, spina bifida, and craniorachischisis.

BACKGROUND A precise temporal and spatial regulation of gene expression is necessary to achieve neural tube closure. Med12, a subunit of the mediator complex, can bind transcription factors and modulate expression of their target genes. Med12 is essential during early mouse development and is important for neural tube closure. METHODS We have made use of a mouse line carrying a conditional nu...